The 27th Annual Meeting of the European Network of Official Medicines Control Laboratories (OMCLs) was held from 13 to 17 June 2022 at the Council of Europe, in Strasbourg (France). Over 230 participants – from 36 countries and representing 60 OMCLs – attended this meeting organised by the European Directorate for the Quality of Medicines & HealthCare (EDQM). Nine sessions were held during the meeting week; the General Session alone drew over 180 participants. This event, after the 4th OMCL Falsified Medicines Symposium held in May in Rome, was the second major in-person meeting of the OMCL Network since restrictive COVID‑19 pandemic measures were lifted.