The European Pharmacopoeia (Ph. Eur.) Commission is consulting its stakeholders on the new version of this major general method which has undergone extensive revision.
This general method, released under the reference 2.2.25, is one of the original cornerstones of pharmacopoeial testing. While it is still referred to in many general texts and in more than 500 individual monographs, the number of these references has nonetheless dropped in the last few decades. This can be explained by the development of infrared spectroscopy for identification tests which has replaced UV-Vis absorption spectrophotometry-based tests and also by the phasing out of assays based on UV-Vis absorbance in favour of titrations or HPLC methods.