WHO International Chemical References Substances (ICRS)

Established, Stored and Distributed by the EDQM


On 16 April 2010, the EDQM took over responsibility for the establishment, storage and distribution of WHO ICRS from Apoteket AB, the previous WHO Collaborating Centre for these substances.

ICRS are adopted by the WHO Expert Committee on Specifications for Pharmaceutical Preparations. They are intended primarily for use in physical and chemical tests and assays described in the specifications published in ‘The International Pharmacopoeia' for the quality control of pharmaceutical substances.

ICRS Establishment Studies

The EDQM organises international collaborative studies to establish new standards when required, with the WHO's assistance.

Looking for ICRS Standards?

Search for availability, price, leaflets and safety data sheets (SDS) using the ICRS Database.


ICRS Reference Database


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Press Release

EDQM & WHO Announce New Collaboration


Related Links

WHO The International Pharmacopoeia (Ph. Int.)

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